A fire fueled by hot and windy conditions exploded Friday in Siskiyou County, raging through a neighborhood in Weed and destroying scores of homes and other buildings.

The Lincoln Heights area of Weed was hard hit, with rows of homes lost in the subdivision.

8:26 p.m. Sept. 2, 2022 An earlier version of this article incorrectly stated the McKinney fire killed two people and destroyed 132 structures. It killed four people and destroyed 185 structures.

7:56 p.m. Sept. 2, 2022 An earlier version of this article incorrectly stated the name of the state fire agency as the California Department of Forestry and Fire Prevention. It is the California Department of Forestry and Fire Protection.

An unknown number of civilians were treated and transported to nearby facilities for injuries related to the fire, said Suzi Brady, a spokesperson for the California Department of Forestry and Fire Protection’s Siskiyou unit. She did not know how many civilians were injured, how they were injured or their conditions.

Weed Mayor Kim Greene told The Times she was at a community center when the fire started at Roseburg Forest Products, a nearby lumber mill.

The blaze quickly gained power. By the time the mayor walked outside, she could hear explosions coming from an area with plumes of black smoke. The fire soon spread to a residential neighborhood.

Greene couldn’t confirm how many homes were destroyed.

The Associated Press quoted local fire officials as saying about 100 structures were lost.

The mayor went back into the community center and told the few people present to evacuate. She drove out of the area, stopping near Weed Airport to take pictures.

“It just felt like it was following me,” she said.

The Mill fire continued to grow Friday night as crews contended with wind gusts up to 36 mph and extremely dry fuels, Brady said. The blaze was burning among grasses, brush and timber.

Gov. Gavin Newsom on Friday night declared a state of emergency for Siskiyou County due to the fire.

Weed residents recalled the impact of the Boles fire, which broke out Sept. 15, 2014, burning more than 500 acres and destroying 150 homes and other structures, the mayor said.

“Half of our town burned,” Greene said. “Everybody was affected. We all still have some PTSD from that.”

In Siskiyou County, already hit hard this year by the McKinney fire near Yreka, residents know to heed evacuation orders, she added.

Greene was at her home Friday evening, monitoring the fire’s progress. It appeared to be moving to the north, away from her location, she said. Nevertheless, she wasn’t taking chances. The mayor told her neighbors to pack up and evacuate; she too was ready to leave at a moment’s notice.

“We’re leaving a lot of things behind,” she said. “The important things are in vehicles. The trailer’s hooked up.”

The Mill fire has also forced evacuations in Shastina and Edgewood, according to CalFire. Students at Weed High School were evacuated via buses to Mount Shasta High School.

An evacuation shelter has been set up at the Kahtishraam Wellness Center in Yreka. Large animals are being sent to the Siskiyou County Fairgrounds in Yreka.

“We’re doing the exact same thing we did two weeks ago,” said Cliff Munson, who heads the fairgrounds, referring to the McKinney fire in July, which scorched more than 60,000 acres, killed four people and destroyed 185 structures.

Siskiyou County residents, still reeling from that fire, have sued PacifiCorp, a utility serving the area, alleging that sparks from its high-voltage transmission lines and other equipment ignited the blaze.

As residents and workers on Friday left parts of Weed, which has a population of about 2,600, most of the city was without power; Pacific Power, the utility company there, reported an outage around 1:30 p.m. affecting 7,625 homes and businesses.

Flames appeared to be hollowing out a large commercial structure near the mill in the northern part of the city, according to images on social media. The mill is adjacent to rows of single-family homes.

“We’re closing up the building and trying to get out of the way,” said a social services worker at the Shasta View Nursing Center, just hundreds of feet from where the fire was burning. She and other staff had evacuated 25 long-term residents and rehabilitation patients.

The National Weather Service issued a red flag warning Friday for the Northern California area near Mt. Shasta where the blaze is burning, due to the hot, dry conditions. Temperatures were hovering at 94 degrees, with winds of up to 35 mph.

The gusts died down Friday night, but the fire was actively burning, Brady said.

Siskiyou County was dealt another blow Friday, as a new fire sprung up to the northwest, between Yreka and Weed.

The Mountain fire was first reported around 3:45 p.m. and had grown to at least 300 acres Friday night, Brady said. It was uncontained and burning in timber about a mile east of Gazelle Mountain, she said. Crews noted that the fire was crowning — lighting the tops of trees like torches, a sign of intense activity.

Evacuation orders were in place.

The causes of both fires remain under investigation, Brady said.

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Melissa Hernandez is a reporter at the Los Angeles Times. She was formerly an intern for The Times’ 2021 summer internship program, during which she covered general assignments on the Metro desk. Hernandez is a University of Florida graduate, where she studied journalism and environmental science, and is a member of the 2021-22 Los Angeles Times Fellowship class.

Jonah Valdez is a reporter at the Los Angeles Times. Before joining The Times, he worked for the Southern California News Group, where he covered breaking news and wrote award-winning feature stories on topics such as mass shootings, labor and human trafficking, and movements for racial justice. Valdez was raised in San Diego and attended La Sierra University in Riverside, where he edited the campus newspaper. Before graduating, Valdez interned at his hometown paper, the San Diego Union-Tribune, with its Watchdog investigations team. His previous work can be found in Voice of San Diego and the San Diego Reader. When not working, Valdez finds joy in writing and reading poetry, running, thrifting and experiencing food and music with friends and family. He is a member of the 2021-22 Los Angeles Times Fellowship class.

Gregory Yee is a reporter for the Los Angeles Times. Before joining the newsroom in 2021, he spent five years covering criminal justice and breaking news for the Post and Courier in Charleston, S.C. He is a native Southern Californian and graduated from UC Irvine in 2012 with a degree in journalism and Spanish literature.

8:26 p.m. Sept. 2, 2022: An earlier version of this article incorrectly stated the McKinney fire killed two people and destroyed 132 structures. It killed four people and destroyed 185 structures.

7:56 p.m. Sept. 2, 2022: An earlier version of this article incorrectly stated the name of the state fire agency as the California Department of Forestry and Fire Prevention. It is the California Department of Forestry and Fire Protection.